Description
Vascular endothelial growth factor receptor 1 (VEGF R1), also known as FLT1, is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis.1 VEGFR1 is mainly expressed in vascular endothelial cells but also in peripheral blood monocytes. VEGFR1 signaling promotes lymphangiogenesis as well as angiogenesis mainly by increasing bone marrow–derived macrophage recruitment.2